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Postdoctoral Associate - Disney Lab

at The Scripps Research Institute

Posted: 2/6/2020
Job Status: Full Time
Job Reference #:

Job Description

Requisition Number 06117
Department Name: Chemistry - FL
Position Type: Full Time
Position Title Postdoctoral Associate - Disney Lab
Position Summary:

Multiple postdoctoral positions in RNA chemical biology are available in the Disney group in the Department of Chemistry at The Scripps Research Institute. We are committed to each individual’s development to achieve their short term and long term career goals.
Projects with an emphasis on chemical biology center on development of small molecules that target RNA repeat expansions, the causative agent of many neurological and neuromuscular diseases. In particular, the successful candidate will: (i) design high affinity small molecule binders using the structure of the RNA target, our database of RNA-small molecule interactions, and other computational methods; (ii) fully characterize the molecular recognition of the RNA by the small molecule using biophysical methods; (iii) use optimal compounds to study RNA biology in cells and in vivo; and (iv) expand tools available to manipulate RNA in cells. Candidates with demonstrated experience with the following techniques are highly desirable: mammalian cell culture (patient-derived, iPSCs), RNA-seq, splicing isoform analysis by end point RT-PCR and RT-qPCR, RNA-FISH, high throughput screening methods, and conducting experiments in animal models of disease.
Representative publications in this area from our group include: studying the RNA repeats that cause genetically defined ALS and dementia (see: Neuron. 2014 Sep 3;83(5):1043-50); and developing innovative methods to target the RNAs that cause myotonic muscular dystrophy (see: Nat. Chem. Biol. 2017 Feb;13(2):188-193).

Position Description

A Postdoctoral Associate is a direct pay individual in a Division 3 status. Postdoctoral Associates are appointed positions for the purpose of developing scholarly competence, working under the supervision of a TSRI Faculty member. These appointments are normally not renewed beyond a total of six years. Postdoctoral Associates cannot apply for external funding either as a Principal Investigator or Co-Principal Investigator without prior approval from a Departmental Chair. Postdoctoral Associates do not have consulting privileges.

Location: Florida
Additional Information:
Physical Requirements:

This position works in a laboratory or vivarium environment. Further details of the physical requirements of established essential functions for this position will be addressed/discussed during the interview process.

Basic Qualifications:

Must possess a doctoral degree. A pending doctoral degree may be considered with approval of the Principal Investigator.

Successful candidates will have a proven track record of publishing in high impact journals, have experience in nucleic acids, medicinal chemistry, or chemical biology, and can work successfully as a member of a team. An emphasis will be placed on candidates that have a track record of high impact publications. Expertise with RNA-seq data analysis and chemical and structural biology is highly desired.

Interested applicants should send their CV and three letters of reference to A full description of the group’s research focus is available on the web at

Preferred Qualifications:
Compensation: Commensurate with experience
Job Closing Date:
Open Until Filled Yes
Job Posting Category Postdoctoral
EEO Statement

The Scripps Research Institute is an Equal Opportunity Employer. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status.

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